Cyclohexane

Description

Cyclohexane is obtained by the distillation of petroleum or by hydrogenation of benzene. It constitutes 0.5–1.0% of petroleum

Description

Cyclohexane is a colorless liquid with a detergent-like odor. It is used occasionally in organic chemistry as a solvent/co-solvent for purposes such as silica gel purifications or compound recrystallizations.

The Uses of Cyclohexane

Solvent for lacquers and resins. Paint and varnish remover. In the extraction of essential oils. In analytical chemistry for mol wt determinations (cryoscopic constant 20.3). In the manufacture of adipic acid, benzene, cyclohexyl chloride, nitrocyclohexane, cyclohexanol and cyclohexanone. In the manufacture of solid fuel for camp stoves. In fungicidal formulations (possesses slight fungicidal action). In the industrial recrystallization of steroids.

The Uses of Cyclohexane

A suspension of NaH (60% dispersion on mineral oil, 413 mg, 10.32 mmol) in dry DMF (12 mL) at 0 C was treated dropwise with the thiol (B) (1.21 mL, 10.32 mmol). After the addition the mixture was stirred at RT for 15 min. The aryl chloride (A) (1.00 g, 3.44 mmol) was added and the reaction mixture was stirred at RT for 18 h, 80 C for 8 h, then allowed to cool overnight. The mixture was diluted with EtOAc, washed with H2O, brine, dried (Na2SO4), and concentrated in vacuo. The resulting material was purified by silica gel column chromatography (30-50% EtOAc/cyclohexane) to provide the product. [659 mg, 51%]