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koumine

koumine Structural

What is koumine?

Description

The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).

Occurrence

Koumine is an alkaloid isolated from Gelsemium elegans Benth.

The Uses of koumine

Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.

References

Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)

Properties of koumine

Melting point: 168℃
Boiling point: 436.5±45.0 °C(Predicted)
Density  1.42
storage temp.  2-8°C
solubility  DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic)
form  powder
pka 8.67±0.40(Predicted)
color  Yellow-brown

Safety information for koumine

Computed Descriptors for koumine

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