Catharanthine
Synonym(s):(+)-3,4-Didehydrocoronaridine;(2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester;7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester
- CAS NO.：2468-21-5
- Empirical Formula: C21H24N2O2
- Molecular Weight: 336.43
- MDL number: MFCD01753356
- EINECS: 219-586-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Catharanthine?
Chemical properties
Off-White to Pale Beige Solid
The Uses of Catharanthine
Catharanthine is an indole alkaloid analog and an inhibitor of TRPM8.
The Uses of Catharanthine
Precursor of Vinblastine-type alkaloids
The Uses of Catharanthine
Anticancer
What are the applications of Application
Catharanthine base is an alkaloids present in Catharanthus roseus
Definition
ChEBI: Catharanthine is an organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine. It is a bridged compound, an organic heteropentacyclic compound, a methyl ester, a monoterpenoid indole alkaloid, a tertiary amino compound and an alkaloid ester. It is a conjugate base of a catharanthine(1+).
Properties of Catharanthine
| Melting point: | 138-1400C |
| Boiling point: | 472.9°C (rough estimate) |
| alpha | D27 +29.8° (CHCl3) |
| Density | 1.1367 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble5mg/mL (clear solution; warmed) |
| form | powder |
| pka | 6.8(at 25℃) |
| color | white to beige |
| optical activity | [α]/D +30 to +38° (c=0.5, CDCl3) |
Safety information for Catharanthine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Catharanthine
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