LICOCHALCONE-A

Synonym(s):(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one;(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one;4′,4-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone;Licochalcone-A, Synthetic - CAS 58749-22-7 - Calbiochem

CAS NO.：58749-22-7
Empirical Formula: C21H22O4
Molecular Weight: 338.4
MDL number: MFCD01417903
EINECS: 635-678-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-03 18:42:19

What is LICOCHALCONE-A?

The Uses of LICOCHALCONE-A

Licochalcone A is an estrogenic flavonoid that induces apoptosis in multiple types of cancer cells. Licochalcone A applied to bone marrow mesenchymal stem cells (BMSC)-aggregate has strong osteogenetic differentiation thus providing a promising strategy in treating osteoporotic weight-bearing bone fractures with defects.

What are the applications of Application

Licochalcone A is a flavonoid capable of inhibiting Bcl-2 expression and inducing apoptosis

Definition

ChEBI: Licochalcone A is a member of chalcones.

General Description

An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

Biochem/physiol Actions

Inhibits vegetative growth of spore-forming bacteria, B. subtilis and other food-contaminating microorganisms.

Properties of LICOCHALCONE-A

Melting point:	100°
Boiling point:	532.6±50.0 °C(Predicted)
Density	1.171±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF:25.0(Max Conc. mg/mL);73.88(Max Conc. mM) DMSO:37.67(Max Conc. mg/mL);111.31(Max Conc. mM) Ethanol:43.5(Max Conc. mg/mL);128.54(Max Conc. mM)
pka	7.82±0.15(Predicted)
form	Yellow solid
color	Yellow-orange
BRN	4534154

Safety information for LICOCHALCONE-A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.