Diammonium glycyrrhizinate
- CAS NO.:79165-06-3
- Empirical Formula: C42H65NO16
- Molecular Weight: 839.97
- MDL number: MFCD10566634
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Diammonium glycyrrhizinate?
Description
Diammonium Glycyrrhizinate is the diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase.
Occurrence
Diammonium glycyrrhizinate, a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae).
The Uses of Diammonium glycyrrhizinate
Diammonium glycyrrhizinate (DG) is an ammonium salt preparation of 18-alpha-glycyrrhizin—exhibits antiinflammation, immunomodulation, anti-anaphylaxis, and membranous protection effects.Currently, the family of glycyrrhizin is used in clinical practice as an effective liver protector against most hepatic diseases such as chronic viral hepatitis, drug-induced liver injury, nonalcoholic fatty liver disease, autoimmune hepatitis, and hepatocellular carcinoma.
Properties of Diammonium glycyrrhizinate
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Soluble in DMSO |
form | Solid |
color | White to off-white |
Safety information for Diammonium glycyrrhizinate
Computed Descriptors for Diammonium glycyrrhizinate
New Products
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