JAK3 Inhibitor
Synonym(s):4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem
- CAS NO.:211555-04-3
- Empirical Formula: C16H14BrN3O3
- Molecular Weight: 376.2
- MDL number: MFCD02179366
- EINECS: 809-014-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 21:40:10
What is JAK3 Inhibitor?
Description
WHI-
The Uses of JAK3 Inhibitor
WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.
The Uses of JAK3 Inhibitor
WHI-P154 can act as antileukemic agent with apoptosis inducing activity.
What are the applications of Application
WHI-P 154 is a JAK3 inhibitor which inhibits other common kinases
Biochem/physiol Actions
WHI-P154 is a specific inhibitor of JAK3 (IC50 = 1.8 μM) with no inhibitory activity against JAK1 or JAK2. WHI-P154 enhances myogenic differentiation of C2C12 mouse myoblast cells, and induces differentiation of neural progenitor cells. The compound WHI-P154 dose dependently inhibits expression of iNOS and NO production in LPS-challenged macrophages.
in vitro
kinase assays show that whi-p154 is not a specific inhibitor. besides jak3, it also inhibits many other kinases, including egfr, abl, lck, src and vegfr. whi-p154 inhibits egfr with ic50 value of 4nm. the specificity of whi-p154 has not been shown in cell-based assays either [1].
storage
Store at RT
References
[1] changelian ps, moshinsky d, kuhn cf, flanagan me, munchhof mj, harris tm, whipple da, doty jl, sun j, kent cr, magnuson ks, perregaux dg, sawyer ps, kudlacz em. the specificity of jak3 kinase inhibitors. blood. 2008 feb 15;111(4):2155-7.
[2] narla rk, liu xp, myers de, uckun fm. 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. clin cancer res. 1998 jun;4(6):1405-14.
Properties of JAK3 Inhibitor
Melting point: | 230 °C |
Boiling point: | 470.3±45.0 °C(Predicted) |
Density | 1.576±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble1mg/mL, clear (warmed) |
pka | 8.57±0.31(Predicted) |
form | powder |
color | white to brown |
CAS DataBase Reference | 211555-04-3 |
Safety information for JAK3 Inhibitor
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for JAK3 Inhibitor
InChIKey | CBIAKDAYHRWZCU-UHFFFAOYSA-N |
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