Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
- CAS NO.：211555-08-7
- Empirical Formula: C16H15N3O3
- Molecular Weight: 297.31
- MDL number: MFCD02683970
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
![Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Structural](https://img.chemicalbook.in/CAS/20150408/GIF/211555-08-7.gif)
What is Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-?
What are the applications of Application
WHI-P180, Hydrochloride is an IgE-mediated mast cell response inhibitor
Biological Activity
WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.
in vivo
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
Properties of Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
| Boiling point: | 476.5±40.0 °C(Predicted) |
| Density | 1.336±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 9.58±0.10(Predicted) |
| color | White to off-white |
Safety information for Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
Computed Descriptors for Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
New Products
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