Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
- CAS NO.：211555-08-7
- Empirical Formula: C16H15N3O3
- Molecular Weight: 297.31
- MDL number: MFCD02683970
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
![Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Structural](https://img.chemicalbook.in/CAS/20150408/GIF/211555-08-7.gif)
What is Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-?
What are the applications of Application
WHI-P180, Hydrochloride is an IgE-mediated mast cell response inhibitor
Biological Activity
WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.
in vivo
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
Properties of Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
| Boiling point: | 476.5±40.0 °C(Predicted) |
| Density | 1.336±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 9.58±0.10(Predicted) |
| color | White to off-white |
Safety information for Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
Computed Descriptors for Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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