Isobutyl nitrite

CAS NO.：542-56-3
Empirical Formula: C4H9NO2
Molecular Weight: 103.12
MDL number: MFCD00002056
EINECS: 208-819-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 13:37:16

What is Isobutyl nitrite?

Chemical properties

Isobutyl nitrite is a colourless to pale yellow liquid and has a pleasant and fruity odor.

The Uses of Isobutyl nitrite

Isobutyl nitrite is an alkyl nitrite. It is mainly used in “poppers”, consumed as a recreational drug for their psychoactive effects. Poppers are illegal in many countries, and as a result are commonly sold as air fresheners or deodorizers. Other minor uses of isobutyl nitrite include as an intermediate in the synthesis of aliphatic nitrites, nail polish removers, video head cleaners, fuels, and jet propellants.
Isobutyl nitrite was used to study inhalant-induced immunotoxicity. It is used in the preparation of plasmoquin.

What are the applications of Application

Isobutyl nitrite is an ester of isobutanol and nitrous acid

Preparation

Isobutyl nitrite is synthesized by reacting isobutyl alcohol with sodium nitrite in dilute sulfuric acid (NTP, 1996).

Definition

ChEBI: Isobutyl nitrite is a member of nitrite esters. It derives from an isobutanol.

General Description

Isobutyl nitrite is an ester of isobutanol and nitrous acid, which has a various range of household and industrial applications. It is commonly added to a number of household cleaning liquids and air fresheners. As a volatile liquid, it also serves as a "room odorizer" which is widely sold without a prescription.
Besides, Isobutyl nitrite has also been applied in pharmaceuticals, in which it acts as a vasodilator (blood vessel relaxant) and is used medically as part of the emergency antidote for cyanide poisoning.

Air & Water Reactions

Highly flammable. Insoluble in water. Slowly decomposes in water.

Reactivity Profile

An oxidizing agent but can serve as a reducing agent. May begin a vigorous reaction that culminates in a detonation if mixed with reducing agents, including hydrides, sulfides, nitrides, ammonium salts, cyanides, and many fuels.

Fire Hazard

Isobutylnitrite is flammable.

References

https://en.wikipedia.org/wiki/Isobutyl_nitrite
https://www.ncbi.nlm.nih.gov/pubmed/3698454
http://amylnitrite.org/isobutyl

Properties of Isobutyl nitrite

Boiling point:	66-67 °C(lit.)
Density	0.87 g/mL at 25 °C(lit.)
refractive index	n20/D 1.373(lit.)
Flash point:	−6 °F
storage temp.	0-6°C
form	clear liquid
color	Light yellow to Yellow to Orange
Water Solubility	<0.1 g/100 mL (19 ºC)
Sensitive	Light Sensitive/Air Sensitive
Merck	14,5149
BRN	1699518
Exposure limits	ACGIH: Ceiling 1 ppm
Stability:	Stable. Incompatible with acids, alcohols, strong bases. Decomposes slowly in water. Flammable - incompatible with strong oxidizing agents. Note wide explosion limits. May be light and moisture sensitive. Oxidizer. May explode if heated.
CAS DataBase Reference	542-56-3(CAS DataBase Reference)
NIST Chemistry Reference	(CH3)2CHCH2ONO(542-56-3)
IARC	2B (Vol. 122) 2019
EPA Substance Registry System	Isobutyl nitrite (542-56-3)

Safety information for Isobutyl nitrite

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H341:Germ cell mutagenicity H350:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention.