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HomeProduct name listIONOMYCIN CALCIUM SALT

IONOMYCIN CALCIUM SALT

Synonym(s):Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem

  • CAS NO.:56092-82-1
  • Empirical Formula: C41H70CaO9
  • Molecular Weight: 747.07
  • MDL number: MFCD00083634
  • EINECS: 617-954-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
IONOMYCIN CALCIUM SALT Structural

What is IONOMYCIN CALCIUM SALT?

Description

Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.

Chemical properties

Powder

The Uses of IONOMYCIN CALCIUM SALT

Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.

The Uses of IONOMYCIN CALCIUM SALT

Ionomycin is more effectivethan A23187 as a Ca++ionophore; Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons.

What are the applications of Application

Ionomycin calcium salt (1 mM solution in DMSO) is a selective ionophore and an ion carrier for Ca2+.

What are the applications of Application

Ionomycin is a reversible ion binding calcium ionophore, polyether antibiotic, and apoptotic degeneration inducer

General Description

Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).

Biological Activity

Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).

Biochem/physiol Actions

Product does not compete with ATP.

storage

-20°C

References

Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815 Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892

Properties of IONOMYCIN CALCIUM SALT

Melting point: 205-206 C
Flash point: 87 °C
storage temp.  −20°C
solubility  Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
form  White to off-white solid
color  white to off-white
Sensitive  Light Sensitive
BRN  1416163
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety information for IONOMYCIN CALCIUM SALT

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for IONOMYCIN CALCIUM SALT

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