AFC
- CAS NO.:135304-07-3
- Empirical Formula: C20H33NO3S
- Molecular Weight: 367.55
- MDL number: MFCD00871540
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is AFC?
Description
N-
Chemical properties
Yellow-red oil
The Uses of AFC
Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.
What are the applications of Application
N-Acetyl-S-farnesyl-L-cysteine (AFC) is an inhibitor of S-farnesylcysteine methyl transferase
Definition
ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.
References
1) Volker?et al.?(1991),?Effects of farnesylcyteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem.?266?21515 2) Xu?et al.?(1996),?Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol.?50?1495 3) Rosado and Sage (2000),?Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J.?347?183 4) Gordon?et al.?(2008),?Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol.?128?643 5) Adhami?et al.?(2012),?N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells;?Exp. Dermatol.?21?700
Properties of AFC
Boiling point: | 566.1±50.0 °C(Predicted) |
Density | 1.038±0.06 g/cm3(Predicted) |
storage temp. | -15°C |
solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) |
form | Pale yellow oil. |
pka | 3.31±0.10(Predicted) |
color | Yellow |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for AFC
Computed Descriptors for AFC
New Products
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