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AFC

AFC Structural

What is AFC?

Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Chemical properties

Yellow-red oil

The Uses of AFC

Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.

What are the applications of Application

N-Acetyl-S-farnesyl-L-cysteine (AFC) is an inhibitor of S-farnesylcysteine methyl transferase

Definition

ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.

References

1) Volker?et al.?(1991),?Effects of farnesylcyteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem.?266?21515 2) Xu?et al.?(1996),?Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol.?50?1495 3) Rosado and Sage (2000),?Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J.?347?183 4) Gordon?et al.?(2008),?Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol.?128?643 5) Adhami?et al.?(2012),?N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells;?Exp. Dermatol.?21?700

Properties of AFC

Boiling point: 566.1±50.0 °C(Predicted)
Density  1.038±0.06 g/cm3(Predicted)
storage temp.  -15°C
solubility  Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
form  Pale yellow oil.
pka 3.31±0.10(Predicted)
color  Yellow
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety information for AFC

Computed Descriptors for AFC

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