Indinavir sulfate

Description

Indinavir is an HIV-1 protease inhibitor (K_i = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (K_i = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (K_is = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC₉₅s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.

Chemical properties

Crystalline Solid

The Uses of Indinavir sulfate

Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.

What are the applications of Application

Indinavir Sulfate is a member of the hydroxyaminopentane amide class of HIV-1 protease inhibitors

Definition

ChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir.

brand name

Crixivan (Merck).

Hazard

Moderately toxic by ingestion.

storage

RT