Indinavir sulfate
- CAS NO.：157810-81-6
- Empirical Formula: C36H49N5O8S
- Molecular Weight: 711.87
- MDL number: MFCD00920346
- EINECS: 682-418-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is Indinavir sulfate?
Description
Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.
Chemical properties
Crystalline Solid
The Uses of Indinavir sulfate
Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.
What are the applications of Application
Indinavir Sulfate is a member of the hydroxyaminopentane amide class of HIV-1 protease inhibitors
Definition
ChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir.
brand name
Crixivan (Merck).
Hazard
Moderately toxic by ingestion.
storage
RT
Properties of Indinavir sulfate
| Melting point: | 150-153°C (dec) |
| storage temp. | -20°C Freezer |
| solubility | Freely soluble in water, soluble in methanol, practically insoluble in heptane. |
| form | Solid |
| color | White to Off-White |
| Water Solubility | >100g/L(temperature not stated) |
Safety information for Indinavir sulfate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Indinavir sulfate
Abamectin manufacturer
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