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HomeProduct name listHYDROCORTISONE CYPIONATE (200 MG)

HYDROCORTISONE CYPIONATE (200 MG)

  • CAS NO.:508-99-6
  • Empirical Formula: C29H42O6
  • Molecular Weight: 486.64
  • MDL number: MFCD00083363
  • EINECS: 208-091-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
HYDROCORTISONE CYPIONATE (200 MG) Structural

What is HYDROCORTISONE CYPIONATE (200 MG)?

Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

The Uses of HYDROCORTISONE CYPIONATE (200 MG)

Hydrocortisone Cypionate is a metabolite of Hydrocortisone (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids.

Indications

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Definition

ChEBI: Hydrocortisone cypionate is a corticosteroid hormone.

brand name

Cortef (Pharmacia & Upjohn).

Pharmacokinetics

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Metabolism

Primarily hepatic via CYP3A4

Properties of HYDROCORTISONE CYPIONATE (200 MG)

Boiling point: 645.0±55.0 °C(Predicted)
Density  1.22±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO: 125 mg/mL (256.86 mM)
form  Solid
pka 12.33±0.70(Predicted)
color  White to off-white

Safety information for HYDROCORTISONE CYPIONATE (200 MG)

Computed Descriptors for HYDROCORTISONE CYPIONATE (200 MG)

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