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HomeProduct name listGNE 7915

GNE 7915

GNE 7915 Structural

What is GNE 7915?

The Uses of GNE 7915

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

The Uses of GNE 7915

GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).

Properties of GNE 7915

Melting point: 143 - 144°C
Boiling point: 629.9±65.0 °C(Predicted)
Density  1.404±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Chloroform (Slightly), DMSO (Slightly)
form  solid
pka 2.80±0.10(Predicted)
color  Off-white to light yellow
CAS DataBase Reference 1351761-44-8

Safety information for GNE 7915

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for GNE 7915

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