GNE 7915
- CAS NO.:1351761-44-8
- Empirical Formula: C19H21F4N5O3
- Molecular Weight: 443.4
- MDL number: MFCD25977005
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is GNE 7915?
The Uses of GNE 7915
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
The Uses of GNE 7915
GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).
Properties of GNE 7915
Melting point: | 143 - 144°C |
Boiling point: | 629.9±65.0 °C(Predicted) |
Density | 1.404±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Chloroform (Slightly), DMSO (Slightly) |
form | solid |
pka | 2.80±0.10(Predicted) |
color | Off-white to light yellow |
CAS DataBase Reference | 1351761-44-8 |
Safety information for GNE 7915
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GNE 7915
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