CX-4945
- CAS NO.:1009820-21-6
- Empirical Formula: C19H12ClN3O2
- Molecular Weight: 349.77
- MDL number: MFCD13184796
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is CX-4945?
The Uses of CX-4945
CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.
What are the applications of Application
CX-4945 is an ATP-competitive CK2 protein kinase inhibitor, able to suppress Akt signaling and inhibit HUVEC proliferation.
Biological Activity
cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]
References
[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.
Properties of CX-4945
Boiling point: | 568.5±50.0 °C(Predicted) |
Density | 1.490 |
storage temp. | Store at -20°C |
solubility | ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
pka | 2.96±0.30(Predicted) |
form | Orange powder. |
color | Yellow to orange |
Safety information for CX-4945
Computed Descriptors for CX-4945
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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