Gallic acid monohydrate

Synonym(s):3,4,5-Trihydroxybenzoic acid monohydrate

CAS NO.：5995-86-8
Empirical Formula: C7H8O6
Molecular Weight: 188.13
MDL number: MFCD00002510
EINECS: 611-919-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-24 22:20:23

What is Gallic acid monohydrate?

Chemical properties

Off-white to beige powder

The Uses of Gallic acid monohydrate

Gallic acid monohydrate may be used as a standard in the photometric determination of total phenolics content by Folin-Ciocalteu method.

The Uses of Gallic acid monohydrate

Gallic Acid is a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities.

The Uses of Gallic acid monohydrate

anti-hyperlipoproteinemic, selective, reversible, competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

General Description

Gallic acid monohydrate is a phenolic acid. A study of its crystalline structure reveals that it is planar with two intramolecular hydrogen bonds and five intermolecular hydrogen bonds. Gallic acid is of significant importance because of its antioxidant and anti-cancer activities. Infrared and Raman spectral studies of gallic acid have been reported.

Purification Methods

Crystallise gallic from water. The tri-O-acetyl derivative has m 172o (from MeOH), and the anilide has m 207o(from EtOH). [Beilstein 10 H 470, 10 IV 1993.]

Properties of Gallic acid monohydrate

Melting point:	252 °C (dec.)(lit.)
Density	1.694
Flash point:	250 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	It is soluble in alcohol, ether, glycerol, acetone negligible in benzene, chloroform, petroleum ether.
form	Solid
color	White to cream
Water Solubility	15 g/l (20 ºC)
Sensitive	Hygroscopic
Merck	14,4345
BRN	2050274
Stability:	Light Sensitive
InChI	InChI=1S/C7H6O5.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;/h1-2,8-10H,(H,11,12);1H2
CAS DataBase Reference	5995-86-8(CAS DataBase Reference)

Safety information for Gallic acid monohydrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.