Fluocortolone
- CAS NO.:152-97-6
- Empirical Formula: C22H29FO4
- Molecular Weight: 376.46
- MDL number: MFCD00867463
- EINECS: 205-811-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:04
What is Fluocortolone?
Chemical properties
Pale Yellow Solid
Originator
Ultralan,Schering,W. Germany,1965
The Uses of Fluocortolone
Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.
What are the applications of Application
Fluocortolone is a glucocorticoid steroid
Background
Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Definition
ChEBI: Fluocortolone is a 21-hydroxy steroid.
Manufacturing Process
(a) 16α-Methyl-6α-Fluoro-δ4-11β,21-Diol-3,20-Dione:16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate (MP 132°/134° to 138°C, UVε238=
15,000) is hydroxylated with Curvularia lunata in 11β-position using the
fermentation method whereby the 21-acetate group is simultaneously
saponified. The hitherto unknown starting material 16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate is obtained from 16α-methyl-δ5-
pregnene-3β,21-diol-20-one-21-acetate, MP 152° to 154°C, by the addition of
bromofluorine (from N-bromoacetamide and hydrogen fluoride) onto the 5-6
double bond, oxidation of the 3β-hydroxyl group with chromic acid,
introduction of the δ4-double bond by splitting of the hydrogen bromide and
acid isomerization of the 6β-fluoro substituent to the 16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate. By chromatographic purification on
silica gel the 16α-methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is: MP
166°/167° to 171°C.
(b) 16α-Methyl-6α-Fluoro-δ4-Pregnene-11β,21-Diol-3,20-Dione-21-Acetate:By
reaction of the compound of (a) with acetic anhydride in pyridine at room
temperature, the acetate is obtained and recrystallized from ethyl acetate, MP
248°/249° to 251°C.
(c) 16α-Methyl-6α-Fluoro-δ1,4-Pregnadiene-11β,21-Diol-3,20-Dione:16α-
methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is dehydrogenated with
Corynebacterium simplex. The extraction residue is subjected to
chromatography on silica gel and after recrystallization there is obtained from
methylene chloride-isopropyl ether 16α-methyl-6α-fluoro-δ1,4-pregnadiene-
11β,21-diol-3,20-dione, MP 180°/181° to 182°C.
Therapeutic Function
Glucocorticoid
Flammability and Explosibility
Not classified
Metabolism
Not Available
Properties of Fluocortolone
Melting point: | 113-116°C |
alpha | D20 +100° (dioxane) |
Boiling point: | 537.4±50.0 °C(Predicted) |
Density | 1.1001 (estimate) |
vapor pressure | 0.001Pa at 25℃ |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly) |
form | Solid |
pka | 12.98±0.10(Predicted) |
color | Pale Yellow to Yellow |
Water Solubility | 204mg/L at 20℃ |
Safety information for Fluocortolone
Computed Descriptors for Fluocortolone
New Products
Tubulysin G (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2,2-diethoxyethanethioamide Diethyl Aluminium Cyanide (1.0 M in Toluene) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 1-(1,1-Difluoroethyl)-2-fluorobenzene 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- 3-Aminocyclobutanone hydrochloride Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl 4-(2-fluoro-4- nitrophenyl) thiomorpholine Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
109113-72-6 2-(Chloromethyl)-4-methylquinazoline (2-CMQ) 98%View Details
109113-72-6 -
Hydrogen Gas 98%View Details
-
590-17-0 Bromoacetonitrile 98%View Details
590-17-0 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8