Paramethasone
- CAS NO.:53-33-8
- Empirical Formula: C22H29FO5
- Molecular Weight: 392.46
- MDL number: MFCD03695621
- EINECS: 200-169-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is Paramethasone?
Originator
Haldrone,Lilly,US,1961
The Uses of Paramethasone
Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.
The Uses of Paramethasone
Glucocorticoid.
Definition
ChEBI: Paramethasone is a fluorinated steroid.
Manufacturing Process
A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.
brand name
Haldrone (Lilly).
Therapeutic Function
Glucocorticoid
Properties of Paramethasone
Melting point: | 228-241°C |
Boiling point: | 573.5±50.0 °C(Predicted) |
Density | 1.32±0.1 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 12.34±0.70(Predicted) |
color | White to Pale Beige |
CAS DataBase Reference | 53-33-8 |
Safety information for Paramethasone
Computed Descriptors for Paramethasone
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