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HomeProduct name listParamethasone

Paramethasone

  • CAS NO.:53-33-8
  • Empirical Formula: C22H29FO5
  • Molecular Weight: 392.46
  • MDL number: MFCD03695621
  • EINECS: 200-169-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:39
Paramethasone Structural

What is Paramethasone?

Originator

Haldrone,Lilly,US,1961

The Uses of Paramethasone

Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.

The Uses of Paramethasone

Glucocorticoid.

Definition

ChEBI: Paramethasone is a fluorinated steroid.

Manufacturing Process

A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.

brand name

Haldrone (Lilly).

Therapeutic Function

Glucocorticoid

Properties of Paramethasone

Melting point: 228-241°C
Boiling point: 573.5±50.0 °C(Predicted)
Density  1.32±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 12.34±0.70(Predicted)
color  White to Pale Beige
CAS DataBase Reference 53-33-8

Safety information for Paramethasone

Computed Descriptors for Paramethasone

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