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HomeProduct name listFatostatin A

Fatostatin A

Fatostatin A Structural

What is Fatostatin A?

Description

Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.

The Uses of Fatostatin A

Fatostatin A is Cell permeable inhibitor of SREBP activation.

Definition

ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.

References

1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882 2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329

Properties of Fatostatin A

Boiling point: 474.3±55.0 °C(Predicted)
Density  1.125±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Soluble in DMSO (up to 25 mg/ml).
form  solid
pka 3.46±0.10(Predicted)
color  Yellow
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for Fatostatin A

Computed Descriptors for Fatostatin A

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