Palmitoylethanolamide
Synonym(s):N-(2-Hydroxyethyl)hexadecanamide;N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol;Palmidrol;Palmitoylethanolamide - CAS 544-31-0 - Calbiochem;PEA
- CAS NO.:544-31-0
- Empirical Formula: C18H37NO2
- Molecular Weight: 299.49
- MDL number: MFCD00020562
- EINECS: 208-867-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 17:35:26
What is Palmitoylethanolamide?
Description
Palmitoylethanolamide (PEA) is a fatty acid amide produced in the body that binds to and activates the peroxisome proliferator-activated receptor alpha (PPAR-α). It was initially described as an agonist to the type 2 cannabinoid receptor (CB2), though it is now recognized that PEA does not bind to cannabinoid receptors. PEA is known to have anti-inflammatory, analgesic, and neuroprotective properties. PEA supplements have been used by people with chronic pain as well as those with neuropathic pain.
The Uses of Palmitoylethanolamide
Palmitoylethanolamide is a natural substance produced by the body and it is very effective and safe to use as a supplement for pain and reduce inflammation.
PEA can be synthesized within the human body from the abundant fatty acid palmitic acid, but it is not dependent or influenced by dietary consumption of fatty acids. Palmitic acid in the diet is derived from dairy products such as cheese and butter, palm tree oil, and animal meat products. However, increasing palmitic acid in the hope of increasing endogenous PEA synthesis will not be effective.
The anti-inflammatory properties of PEA are due to its ability to inhibit inflammation-causing proteins called cytokines. Cytokines are released during periods of inflammation. PEA can suppress the secretion of tumor necrosis factor alpha (TNF alpha), a cytokine, while also inhibiting the release of interleukins. Interleukins are a specific class of cytokines which belong in the immunological system and are activated during the process of inflammation.
Chronic Pain and the Use of Palmitoylethanolamide: An Update
What are the applications of Application
Palmitoylethanolamide is an endogenous cannabinoid agonist, FAAH inhibitor, and PPARα agonist.
Properties of Palmitoylethanolamide
Melting point: | 97-98℃ |
Boiling point: | 461.5±28.0 °C(Predicted) |
Density | 0.910±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
form | White solid |
color | White |
Water Solubility | 4.01mg/L at 20℃ |
Safety information for Palmitoylethanolamide
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Environment GHS09 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. |
Computed Descriptors for Palmitoylethanolamide
InChIKey | HXYVTAGFYLMHSO-UHFFFAOYSA-N |
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TRC FINE CHEMS
Heni Chemical Industries (Heni Drugs Pvt Ltd)
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ASolution Pharmaceuticals Pvt Ltd
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