Fatostatin A
Synonym(s):125B11, 2-Propyl-4-(4-(p-tolyl)thiazol-2-yl)pyridine, HBr, SREBP Processing Inhibitor II;25B11 hydrobromide;4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide;Fatostatin - CAS 298197-04-3 - Calbiochem;Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
- CAS NO.:298197-04-3
- Empirical Formula: C18H19BrN2S
- Molecular Weight: 375.33
- MDL number: MFCD00760867
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-29 17:14:30
What is Fatostatin A?
The Uses of Fatostatin A
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP). Fatostatin A reverses hyperglycemia in diabetic mice. Cell permeable. Fatostatin A is used for the treatment and/or prevention of one or more metabolic disorders.
The Uses of Fatostatin A
Fatostatin hydrobromide has been used:
- to study its anti-cancer activity and effects on mitotic microtubule spindle
- to study its effects on stomatal development
- to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)
General Description
Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.
Biological Activity
fatostatin a is an inhibitor of sterol regulatory element binding protein (srebp), which can inhibit the activation of srebp-1 and srebp-2[1].fatostatin a (0.1-1 μm; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known igf1 signaling pathway. fatostatin a inhibits insulin-induced fat formation in 3t3-l1 cells[2].fatostatin a (30 mg/kg; 150 ml; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].[1]. kamisuki s, et al. a small molecule that blocks fat synthesis by inhibiting the activation of srebp. chem biol. 2009, 16(8): 882-92.[2]. choi y, et al. identification of bioactive molecules by adipogenesis profiling of organic compounds. j biol chem. 2003, 278(9): 7320-4.
Biochem/physiol Actions
Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).
storage
Store at +4°C
Properties of Fatostatin A
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
color | light yellow to yellow |
Safety information for Fatostatin A
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fatostatin A
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