E 7010
- CAS NO.：141430-65-1
- Empirical Formula: C18H17N3O4S
- Molecular Weight: 371.41
- MDL number: MFCD00910291
- EINECS: 256-495-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is E 7010?
Description
ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.
What are the applications of Application
ABT 751 is an inhibitor of microtubule polymerization
Definition
ChEBI: N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide.
Properties of E 7010
| Melting point: | 162 °C(dec.) |
| Boiling point: | 551.0±60.0 °C(Predicted) |
| Density | 1.427 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic |
| pka | 7.86±0.40(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Orange |
Safety information for E 7010
Computed Descriptors for E 7010
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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