DODMA
Synonym(s):N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;1,2-Dioleyloxy-3-(dimethylamino)propane;1,2-Dioleyloxy-3-dimethylaminopropane;DODMA
- CAS NO.:104162-47-2
- Empirical Formula: C41H81NO2
- Molecular Weight: 620.09
- MDL number: MFCD22200991
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-14 20:10:21
What is DODMA?
Description
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.
Chemical properties
DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.
The Uses of DODMA
DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.
The Uses of DODMA
1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]
What are the applications of Application
DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).
Biochem/physiol Actions
DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.
Properties of DODMA
Boiling point: | 649.7±55.0 °C(Predicted) |
Density | 0.869±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in Ethanol, DMSO, DMF |
pka | 8.65±0.28(Predicted) |
form | Liquid |
color | Colorless to light yellow |
BRN | 10139013 |
Safety information for DODMA
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for DODMA
InChIKey | GLGLUQVVDHRLQK-WRBBJXAJSA-N |
SMILES | C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC |
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