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HomeProduct name listDODMA

DODMA

Synonym(s):N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;1,2-Dioleyloxy-3-(dimethylamino)propane;1,2-Dioleyloxy-3-dimethylaminopropane;DODMA

DODMA Structural

What is DODMA?

Description

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

Chemical properties

DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.

The Uses of DODMA

DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.

The Uses of DODMA

1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]

What are the applications of Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs).  LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

Properties of DODMA

Boiling point: 649.7±55.0 °C(Predicted)
Density  0.869±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in Ethanol, DMSO, DMF
pka 8.65±0.28(Predicted)
form  Liquid
color  Colorless to light yellow
BRN  10139013

Safety information for DODMA

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H331:Acute toxicity,inhalation
H336:Specific target organ toxicity,single exposure; Narcotic effects
H351:Carcinogenicity
H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P201:Obtain special instructions before use.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.

Computed Descriptors for DODMA

InChIKey GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

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