1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonym(s):PC;DOPC;L -α-Phosphatidylcholine, dioleoyl;L -β,γ-Dioleoyl-α-lecithin;1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; DOPC; PC(18:1(9Z)/18:1(9Z))
- CAS NO.:4235-95-4
- Empirical Formula: C44H84NO8P
- Molecular Weight: 786.12
- MDL number: MFCD00135191
- EINECS: 224-193-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE?
Description
DOPC, also known as 18:1 (?9-Cis) PC, is a phospholipid containing the unsaturated long-chain (18:1) oleic acid inserted at the sn-1 and sn-2 positions. It is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.
Chemical properties
Amorphous white powder
The Uses of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1,2-Dioleoyl-sn-glycero-3-phosphocholine is a phospholipid containing the unsaturated long-chain (18:1) oleic acid inserted at the sn-1 and sn-2 positions. It is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.
The Uses of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1,2-Dioleoyl-sn-glycero-3-phosphocholine has been used for the reconstitution of proteoliposome (PL). It has also been used in the preparation of lipid vesicles.
The Uses of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
18:1 (Δ9-Cis) PC (DOPC) has been used for reproducing the supramolecular structure of the synovial fluid. It may also be used in the liposome preparation and in the preparation of planar supported membranes.
What are the applications of Application
1,2-Dioleoyl PC is a dimonounsaturated fatty acid used for efficient delivery of siRNA
What are the applications of Application
1,2-Dioleoyl-sn-glycero-3-phosphocholine is a phospholipid utilized for liposome production
Definition
ChEBI: 1,2-dioleoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 36:2 in which the phosphatidyl acyl groups at positions 1 and 2 are both oleoyl. It is a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine and a 1,2-di-octadecenoyl-sn-glycero-3-phosphocholine. It is functionally related to an oleic acid. It is a conjugate base of a 1,2-dioleoyl-sn-glycero-3-phosphocholine(1+).
General Description
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Biochem/physiol Actions
18:1 (Δ9-Cis) PC (DOPC) shows high resistance to the toxic effects of dimethyl sulfoxide (DMSO).
Properties of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Melting point: | -21 °C |
storage temp. | -20°C |
solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
form | solution |
color | White to Off-White Sticky |
BRN | 3898070 |
Stability: | Hygroscopic, Light Sensitive |
CAS DataBase Reference | 4235-95-4 |
Safety information for 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
InChIKey | SNKAWJBJQDLSFF-NVKMUCNASA-N |
SMILES | [C@H](OC(=O)CCCCCCC/C=C\CCCCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC |&1:0,r| |
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