1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Synonym(s):PC;DOPC;L-α-Phosphatidylcholine, dioleoyl;L-β,γ-Dioleoyl-α-lecithin;1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; DOPC; PC(18:1(9Z)/18:1(9Z))

CAS NO.：4235-95-4
Empirical Formula: C44H84NO8P
Molecular Weight: 786.12
MDL number: MFCD00135191
EINECS: 224-193-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Structural

What is 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE?

Description

DOPC, also known as 18:1 (?9-Cis) PC, is a phospholipid containing the unsaturated long-chain (18:1) oleic acid inserted at the sn-1 and sn-2 positions. It is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.

Chemical properties

Amorphous white powder

The Uses of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

1,2-Dioleoyl-sn-glycero-3-phosphocholine is a phospholipid containing the unsaturated long-chain (18:1) oleic acid inserted at the sn-1 and sn-2 positions. It is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.

The Uses of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

1,2-Dioleoyl-sn-glycero-3-phosphocholine has been used for the reconstitution of proteoliposome (PL). It has also been used in the preparation of lipid vesicles.

The Uses of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

18:1 (Δ9-Cis) PC (DOPC) has been used for reproducing the supramolecular structure of the synovial fluid. It may also be used in the liposome preparation and in the preparation of planar supported membranes.

What are the applications of Application

1,2-Dioleoyl PC is a dimonounsaturated fatty acid used for efficient delivery of siRNA

What are the applications of Application

1,2-Dioleoyl-sn-glycero-3-phosphocholine is a phospholipid utilized for liposome production

Definition

ChEBI: 1,2-dioleoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 36:2 in which the phosphatidyl acyl groups at positions 1 and 2 are both oleoyl. It is a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine and a 1,2-di-octadecenoyl-sn-glycero-3-phosphocholine. It is functionally related to an oleic acid. It is a conjugate base of a 1,2-dioleoyl-sn-glycero-3-phosphocholine(1+).

General Description

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Biochem/physiol Actions

18:1 (Δ9-Cis) PC (DOPC) shows high resistance to the toxic effects of dimethyl sulfoxide (DMSO).

Properties of 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Melting point:	-21 °C
storage temp.	-20°C
solubility	Chloroform (Slightly, Sonicated), Methanol (Slightly)
form	solution
color	White to Off-White Sticky
BRN	3898070
Stability:	Hygroscopic, Light Sensitive
CAS DataBase Reference	4235-95-4

Safety information for 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention.