1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonym(s):L -β,γ-Dimyristoyl-α-lecithin;1,2-Ditetradecanoyl-sn-glycero-3-phosphocholine;1,2-ditetradecanoyl-sn-glycero-3-phosphocholine; DMPC; PC(14:0/14:0);3-sn-Phosphatidylcholine, 1,2-dimyristoyl
- CAS NO.:18194-24-6
- Empirical Formula: C36H72NO8P
- Molecular Weight: 677.93
- MDL number: MFCD00036901
- EINECS: 242-085-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE?
Description
1,2-
Chemical properties
white powder
The Uses of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1,2-dimyristoyl-sn-glycero-3-phosphocholine is a phospholipid containing 14:0 fatty acids at the sn-1 and sn-2 positions. It is a synthetic phosopholipid that can be used for liposome production in order to study the properties of lipid bilayer.[Cayman Chemical]
The Uses of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1,2-Dimyristoyl-sn-glycero-3-phosphocholine has been used as a standard for phospholipid analysis by LC-ESI-MS.
What are the applications of Application
1,2-Dimyristoyl-sn-glycero-3-phosphocholine is a synthetic phospholipid used to study biological membranes
Definition
ChEBI: A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).
General Description
Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon.
Biochem/physiol Actions
Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.
Purification Methods
It has three forms 1, 2 and '. Recrystallise it from aqueous EtOH or EtOH/Et2O. Its solubility at 22-23o in Et2O is 0.03%, in Me2CO it is 0.06% and in pyridine it is 1.3%. [Baer & Kates J Am Chem Soc 72 942 1950, Baer & Maurakas J Am Chem Soc 74 158 1952, IR: Marinetti & Stotz J Am Chem Soc 76 1347 1954.] The S-isomer with 1H2O is recrystallised from 2,6-dimethylheptan-4-one and has m 226-227o (sintering at 90-95o), and [] 20D -7o (c 6, MeOH/CHCl3 1:1). [Baer & Martin J Biol Chem 193 835 1951, Beilstein 4 IV 1463.]
Properties of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Melting point: | 220°C(lit.) |
storage temp. | -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
BRN | 3921768 |
Stability: | Stable, but heat sensitive - store at -20℃. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 18194-24-6(CAS DataBase Reference) |
Safety information for 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
InChIKey | CITHEXJVPOWHKC-UUWRZZSWSA-N |
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE manufacturer
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