1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Synonym(s):DMPE;PE(14:0/14:0);Tetradecanoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester;L -β,γ-Dimyristoyl-α-cephalin;1,2-Ditetradecanoyl-sn-glycero-3-phosphoethanolamine
- CAS NO.：998-07-2
- Empirical Formula: C33H66NO8P
- Molecular Weight: 635.85
- MDL number: MFCD00036775
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:05
What is 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE?
Description
Phosphatidylethanolamines (PEs) are phospholipids found in biological membranes, serving both structural and functional roles. Different types of PEs are commonly used in the generation of micelles, liposomes, and other types of artificial membranes. 1,2-Dimyristoyl-sn-glycero-3-PE (DMPE) is a phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.
The Uses of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Tetradecanoic Acid (1R)-1-[[[(2-Aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl Ester is a phospholipid serving both structural and functional roles in biological membranes.
What are the applications of Application
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is a high purity phospholipid utilized for liposome production
Purification Methods
Recrystallise the kephalin from EtOH [Bevan & Malkin J Chem Soc 2667 1951]. The R-isomer has m 195-196o (sintering at 130-135o) after recrystallisation from CHCl3/MeOH, and [] D 26 +6.7o (c 8.5, CHCl3/AcOH 9:1). [Baer Can J Biochem Physiol 35 239 1957, Baer et al. J Am Chem Soc 74 152 1952, Beilstein 4 IV 1463.]
Properties of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
| Melting point: | 191.0 to 195.0 °C |
| Boiling point: | 685.6±65.0 °C(Predicted) |
| Density | 1.027±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform: 3 mg/ml |
| pka | 1.17±0.50(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 1730529 |
| CAS DataBase Reference | 998-07-2(CAS DataBase Reference) |
Safety information for 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
| InChIKey | NEZDNQCXEZDCBI-WJOKGBTCSA-N |
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