1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

Synonym(s):DMPE;PE(14:0/14:0);Tetradecanoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester;L-β,γ-Dimyristoyl-α-cephalin;1,2-Ditetradecanoyl-sn-glycero-3-phosphoethanolamine

CAS NO.：998-07-2
Empirical Formula: C33H66NO8P
Molecular Weight: 635.85
MDL number: MFCD00036775
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE Structural

What is 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE?

Description

Phosphatidylethanolamines (PEs) are phospholipids found in biological membranes, serving both structural and functional roles. Different types of PEs are commonly used in the generation of micelles, liposomes, and other types of artificial membranes. 1,2-Dimyristoyl-sn-glycero-3-PE (DMPE) is a phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.

The Uses of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

Tetradecanoic Acid (1R)-1-[[[(2-Aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl Ester is a phospholipid serving both structural and functional roles in biological membranes.

What are the applications of Application

1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is a high purity phospholipid utilized for liposome production

Purification Methods

Recrystallise the kephalin from EtOH [Bevan & Malkin J Chem Soc 2667 1951]. The R-isomer has m 195-196o (sintering at 130-135o) after recrystallisation from CHCl3/MeOH, and [] D 26 +6.7o (c 8.5, CHCl3/AcOH 9:1). [Baer Can J Biochem Physiol 35 239 1957, Baer et al. J Am Chem Soc 74 152 1952, Beilstein 4 IV 1463.]

Properties of 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

Melting point:	191.0 to 195.0 °C
Boiling point:	685.6±65.0 °C(Predicted)
Density	1.027±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform: 3 mg/ml
pka	1.17±0.50(Predicted)
form	powder to crystal
color	White to Almost white
BRN	1730529
CAS DataBase Reference	998-07-2(CAS DataBase Reference)

Safety information for 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.