DIHYDROERGOTAMINE MESYLATE
Synonym(s):Dihydroergotamine methanesulfonate salt
- CAS NO.:6190-39-2
- Empirical Formula: C33H37N5O5.CH4O3S
- Molecular Weight: 679.79
- MDL number: MFCD05618219
- EINECS: 228-235-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is DIHYDROERGOTAMINE MESYLATE?
Description
Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4
Chemical properties
White to Off-White Solid
The Uses of DIHYDROERGOTAMINE MESYLATE
α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.
The Uses of DIHYDROERGOTAMINE MESYLATE
vasoconstrictor, antimigraine
The Uses of DIHYDROERGOTAMINE MESYLATE
Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors
What are the applications of Application
Dihydroergotamine Methanesulfonate Salt is a competitive serotonin antagonist and vasoconstrictor
Definition
ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens on.
brand name
D.H.E. 45 (Valeant); Migranal (Valeant) .
Biological Activity
Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
storage
Room temperature
References
Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655 Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15 Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144 Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33
Properties of DIHYDROERGOTAMINE MESYLATE
Melting point: | 232°C |
refractive index | -20 ° (C=0.25, JP Method) |
storage temp. | Store at RT |
solubility | methanol: 21 mg/mL |
form | powder |
color | white |
Merck | 14,3174 |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 6190-39-2(CAS DataBase Reference) |
Safety information for DIHYDROERGOTAMINE MESYLATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for DIHYDROERGOTAMINE MESYLATE
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