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HomeProduct name listDIHYDROERGOTAMINE MESYLATE

DIHYDROERGOTAMINE MESYLATE

DIHYDROERGOTAMINE MESYLATE Structural

What is DIHYDROERGOTAMINE MESYLATE?

Originator

Redergin,Lek

The Uses of DIHYDROERGOTAMINE MESYLATE

Cognition adjuvant.

Manufacturing Process

Dihydrotoxine is a mixture of three hydrogenated alkaloides of ergot spur. (Claviceps purpurea). 10 g ergotoxine (the mixture of ergocornine, ergocristine, ergocryptine 1:1:1) in 200 ml dioxane and 20 g Pd/BaSO4 were stirred at a H2 pressure 10 atmospheres at 80°C for 5 hours. The catalyst was filtered off, a filtrate was distilled to dryness in vacuum. The residue was in chloroform dissolved and shook with aluminum oxide. The Al2O3 was filtered off, the filtrate was crystallized after adding of hot benzene and cooling. Yield 6-8 g dihydroergotoxine. It crystallized with 1 mol of benzene. MP: 185°C.

brand name

Alkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis).

Therapeutic Function

Vasodilator

Properties of DIHYDROERGOTAMINE MESYLATE

solubility  methanol: 21 mg/mL
form  powder
color  white

Safety information for DIHYDROERGOTAMINE MESYLATE

Computed Descriptors for DIHYDROERGOTAMINE MESYLATE

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