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HomeProduct name listDiatrizoate sodium

Diatrizoate sodium

Synonym(s):3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid, sodium salt;3,5-Diacetamido-2,4,6-triiodobenzoic acid sodium salt;Diatrizoic acid sodium salt hydrate;Sodium diatrizoate

  • CAS NO.:737-31-5
  • Empirical Formula: C11H8I3N2NaO4
  • Molecular Weight: 635.9
  • MDL number: MFCD00051544
  • EINECS: 212-004-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-26 09:24:46
Diatrizoate sodium  Structural

What is Diatrizoate sodium ?

Chemical properties

Diatrizoate sodium is a white or almost white powder that has no odor and a slightly salty taste. It dissolves easily in water but only slightly dissolves in ethanol, and it does not dissolve in ether. A 50% aqueous solution has a pH between 6.5 and 8.0. The substance has an iodine content of approximately 59.9%.

Originator

Hypaque Sodium,Winthrop,US,1955

The Uses of Diatrizoate sodium

Diagnostic aid (radiopaque medium).

What are the applications of Application

Sodium diatrizoate is a density gradient reagent in blood cell separation

Definition

ChEBI: Sodium amidotrizoate is the sodium salt of a benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, often as a mixture with the meglumine salt, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography. It has a role as a radioopaque medium. It is an organoiodine compound and an organic sodium salt. It contains an amidotrizoic acid anion.

Manufacturing Process

3,5-Dinitrobenzoic acid (15.9 g) was dissolved in an equivalent amount of sodium hydroxide solution, and the solution was diluted to 310 ml with water. The solution was refluxed with Raney nickel for fifteen minutes, filtered, and the filtrate was hydrogenated at elevated pressure using platinum oxide catalyst. After the amount of hydrogen calculated to reduce both nitro groups had been absorbed, the mixture was filtered, and the filtrate was acidified with an equal volume of concentrated hydrochloric acid. Iodine monochloride (17 ml) in 100 ml of 6N HCl was then added with stirring. The reaction mixture was allowed to stand for two and one-half hours at room temperature, then diluted with an equal amount of water with vigorous stirring, and the solid material was collected by filtration and recrystallized
from dilute methanol, giving 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid, MP about 135°C with decomposition. The 18.5 g of 3,5-diamino-2,4,6- triiodobenzoic acid was suspended in 150 ml of acetic anhydride containing 5 drops of 70% perchloric acid, and the mixture was heated on a steam bath for three and one-half hours. The reaction mixture was poured into 300 ml of ice water, and then heated on a steam bath until crystallization took place. The solid material was collected by filtration, dissolvedin dilute sodium hydroxide solution, filtered, and hydrochloric acid was added to the filtrate to reprecipitate the acid product. The latter was again dissolved in sodium hydroxide and reprecipitated with acid, giving 9 g of 3,5-diacetamido-2,4,6- triiodobenzoic acid, MP above 250°C.
The acid may be used as the sodium salt or as the meglumate.

brand name

Md (Mallinckrodt); Urovist Sodium (Berlex).

Therapeutic Function

Diagnostic aid (radiopaque medium)

Mode of action

The mechanism of action of Diatrizoate sodium is that it can block the X-rays so that the body structure containing iodine to be delineated in contrast to those structures that free of iodine, further allowing the visualization of those related areas.

Properties of Diatrizoate sodium

Melting point: 261-262° (dec)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  H2O: 0.35 g/mL, slightly turbid, colorless
form  White Powder
color  White to off-white
BRN  4082984
InChI InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1
CAS DataBase Reference 737-31-5(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (737-31-5)

Safety information for Diatrizoate sodium

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Computed Descriptors for Diatrizoate sodium

InChIKey ZEYOIOAKZLALAP-UHFFFAOYSA-M
SMILES C1(NC(=O)C)C(I)=C(C(I)=C(C([O-])=O)C=1I)NC(=O)C.[Na+]

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