D-Glucurone
Synonym(s):D- (+)-Glucurono-6,3-lactone;D -Glucurone;D -Glucurono-6,3-lactone;Glucuronolactone
- CAS NO.:32449-92-6
- Empirical Formula: C6H8O6
- Molecular Weight: 176.12
- MDL number: MFCD00135622
- EINECS: 251-053-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 11:59:05
What is D-Glucurone?
Chemical properties
white crystals or crystalline powder
The Uses of D-Glucurone
D-Glucurone is a glucuronic acid derivative. It is used for treating canine hepatitis.
The Uses of D-Glucurone
D-Glucurono-6,3-lactone is a glucuronic acid derivative studied for its effectiveness against canine hepatitis. It is utilized in the studies such as starting regent in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, required for the preparation of 1-O-acyl glucuronide of the anti-inflammatory drug ML-3000, synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides.
What are the applications of Application
D-Glucurono-3,6-lactone is a glucuronic acid derivative studied for its effectiveness against canine hepatitis
Definition
The γ-lactone of glucuronic acid. Found in plant gums and animal connective tissues.
General Description
D-(+)-Glucuronic acid γ-lactone (Glucourono-γ-lactone, Glucurone or Glycurone) is a carbohydrate derivative. It converted into L-ascorbic acid in animals and human body. Its molecule contains two five-membered rings. Its crystal structure has been studied.
Purification Methods
Dissolve the lactone or mixture of lactone and acid in H2O and concentrate on a steam bath until crystallisation begins. Cool rapidly to room temperature wih stirring. After 2hours the product is filtered off, washed with cold EtOH and dried to m 174-175o and [] D +19.8o (c 5.2, H2O). The amount of free acid can be obtained by titration of an ice-cold aqueous solution with standard alkali. It can be recrystallised from EtOH, EtOH/H2O or MeOH, and the highest recorded m is 180o. [Stacey J Chem Soc 1529 1939, Mehltretter et al. J Am Chem Soc 73 2424 1951, Beilstein 18 III/IV 3055, 18/5 V 33.]
Properties of D-Glucurone
Melting point: | 172-175 °C (lit.) |
Boiling point: | 227.71°C (rough estimate) |
alpha | 19 º (c=10, H2O) |
Density | 1,76 g/cm3 |
refractive index | 18.5 ° (C=5, H2O) |
storage temp. | Store below +30°C. |
solubility | water: soluble25mg/mL, clear, colorless |
form | Crystals or Crystalline Powder |
pka | 11.96±0.60(Predicted) |
color | White |
Odor | at 100.00 %. very mild mentholic |
optical activity | [α]24/D +18.8°, c = 8 in H2O |
Water Solubility | SOLUBLE |
Merck | 14,4467 |
BRN | 83595 |
CAS DataBase Reference | 32449-92-6(CAS DataBase Reference) |
EPA Substance Registry System | D-Glucuronolactone (32449-92-6) |
Safety information for D-Glucurone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for D-Glucurone
InChIKey | OGLCQHRZUSEXNB-IEPORWDDSA-N |
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