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HomeProduct name listDeoxyarbutin

Deoxyarbutin

  • CAS NO.:53936-56-4
  • Empirical Formula: C11H14O3
  • Molecular Weight: 194.23
  • MDL number: MFCD09970981
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
Deoxyarbutin Structural

What is Deoxyarbutin?

Description

Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.

The Uses of Deoxyarbutin

Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.

Preparation

Deoxyarbutin is a derivative of ?-arbutin, obtained by removal of hydroxyl groups from the glucose side-chain of ?-arbutin.

Properties of Deoxyarbutin

Melting point: 88-89 °C(Solv: ligroine (8032-32-4))
Boiling point: 349.8±32.0 °C(Predicted)
Density  1.174
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
form  Solid
pka 10.10±0.15(Predicted)
color  White to Off-White
Stability: Hygroscopic

Safety information for Deoxyarbutin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Deoxyarbutin

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