Deoxyarbutin
- CAS NO.：53936-56-4
- Empirical Formula: C11H14O3
- Molecular Weight: 194.23
- MDL number: MFCD09970981
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-11 20:10:50
What is Deoxyarbutin?
Description
Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.
The Uses of Deoxyarbutin
Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.
Properties of Deoxyarbutin
| Melting point: | 88-89 °C(Solv: ligroine (8032-32-4)) |
| Boiling point: | 349.8±32.0 °C(Predicted) |
| Density | 1.174 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| color | White to Off-White |
Safety information for Deoxyarbutin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Deoxyarbutin
Abamectin manufacturer
JSK Chemicals
1Y
Phone:+91 9879767970;+919879767970
Whatsapp: +91 9879767970
product: 53936-56-4 Deoxyarbutin, 96% 99%
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