Dabigatran
- CAS NO.:211914-51-1
- Empirical Formula: C25H25N7O3
- Molecular Weight: 471.51
- MDL number: MFCD09837830
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Dabigatran?
Chemical properties
Tan Solid
The Uses of Dabigatran
BIBR 953 (Dabigatran, Pradaxa) is potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM
The Uses of Dabigatran
Nonpeptide, direct thrombin inhibitor. Antithrombotic.
Background
Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate.
What are the applications of Application
Dabigatran is A highly selective, reversible, and potent thrombin inhibitor
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-b ta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.
Biological Activity
bibr 953 is a potent, reversible, and direct inhibitor of thrombin with ic50 value of 9.3nm [1].bibr 953 shows a favorable selectivity profile and strong activity in vitro with a ki value of 4.5nm. it also exhibits the best activity profile in vivo following administration to rats. bibr 953 is designed to be converted into an orally active prodrug bibr 1048 due to its highly polar, zwitterionic nature and poor oral absorption. bibr 953 inhibits thrombin in a competitive fashion. this inhibition is rapid and reversible. bibr 953 inhibits both clot-bound and free thrombin. bibr 953 is demonstrated to have an anticoagulant efficacy both in vitro and ex vivo. since thrombin can affect cell behavior and response in various tissue types via par signaling, bibr 953 is found to be beneficial in many diseases including inflammation, infection, fibrosis and cancer.
Metabolism
Not Available
References
[1] hauel nh, nar h, priepke h, ries u, stassen jm, wienen w. structure-based design of novel potent nonpeptide thrombin inhibitors. j med chem. 2002 apr 25;45(9):1757-66.
[2] van ryn j, goss a, hauel n, wienen w, priepke h, nar h, clemens a. the discovery of dabigatran etexilate. front pharmacol. 2013 feb 12;4:12.
Properties of Dabigatran
Melting point: | 268-272°C |
Boiling point: | 797.1±70.0 °C(Predicted) |
Density | 1.38±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Aqueous Acid |
form | Solid |
pka | 4.17±0.10(Predicted) |
color | White to Brown |
Safety information for Dabigatran
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Dabigatran
Abamectin manufacturer
Ralington Pharma
Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures))
Vijaya Pharma And Life Science
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