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HomeProduct name listCinobufagin

Cinobufagin

  • CAS NO.:470-37-1
  • Empirical Formula: C26H34O6
  • Molecular Weight: 442.55
  • MDL number: MFCD00056825
  • EINECS: 636-927-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Cinobufagin Structural

What is Cinobufagin?

Description

Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.

The Uses of Cinobufagin

Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.

What are the applications of Application

Cinobufagin is specific Na+/K+-ATPase inhibitor with equal effectivity as ouabain

Definition

ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.

Properties of Cinobufagin

Melting point: 133 °C(lit.)
Boiling point: 300 °C(lit.)
Density  1.261 g/cm3
Flash point: >230 °F
storage temp.  2-8°C
solubility  DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
form  powder to crystal
pka 15.10±0.70(Predicted)
color  White to Light yellow

Safety information for Cinobufagin

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H300:Acute toxicity,oral
H310:Acute toxicity,dermal
H330:Acute toxicity,inhalation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P284:Wear respiratory protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P302+P350:IF ON SKIN: Gently wash with plenty of soap and water.

Computed Descriptors for Cinobufagin

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