Cinobufagin
- CAS NO.:470-37-1
- Empirical Formula: C26H34O6
- Molecular Weight: 442.55
- MDL number: MFCD00056825
- EINECS: 636-927-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Cinobufagin?
Description
Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.
The Uses of Cinobufagin
Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
What are the applications of Application
Cinobufagin is specific Na+/K+-ATPase inhibitor with equal effectivity as ouabain
Definition
ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.
Properties of Cinobufagin
Melting point: | 133 °C(lit.) |
Boiling point: | 300 °C(lit.) |
Density | 1.261 g/cm3 |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml |
form | powder to crystal |
pka | 15.10±0.70(Predicted) |
color | White to Light yellow |
Safety information for Cinobufagin
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H300:Acute toxicity,oral H310:Acute toxicity,dermal H330:Acute toxicity,inhalation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P310:Immediately call a POISON CENTER or doctor/physician. P302+P350:IF ON SKIN: Gently wash with plenty of soap and water. |
Computed Descriptors for Cinobufagin
Related products of tetrahydrofuran
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