Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listCholesteryl hemisuccinate

Cholesteryl hemisuccinate

Synonym(s):3β-Hydroxy-5-cholestene 3-hemisuccinate;5-Cholesten-3β-ol 3-hemisuccinate;Cholesteryl hydrogen succinate

  • CAS NO.:1510-21-0
  • Empirical Formula: C31H50O4
  • Molecular Weight: 486.73
  • MDL number: MFCD00037705
  • EINECS: 216-148-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-01 18:08:31
Cholesteryl hemisuccinate Structural

What is Cholesteryl hemisuccinate?

Description

Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.

The Uses of Cholesteryl hemisuccinate

Cholesteryl Hemisuccinate is an oxidation product of polyunsaturated fatty acid of cholesterol that alters lysosome structure and functions and induces proinflammatory cytokine production in macrophages.

Definition

ChEBI: Cholesteryl hemisuccinate is a dicarboxylic acid monoester resulting from the formal condensation of the hydroxy group of cholesterol with one of the carboxy groups of succinic acid. A detergent that is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology. It has a role as a detergent. It is a cholestane ester, a dicarboxylic acid monoester and a hemisuccinate. It is functionally related to a cholesterol.

General Description

Cholesteryl hemisuccinate (CHEMS) is an acidic cholesterol ester.

Biochem/physiol Actions

CHEMS can help to maintain the stability of dioleoylphosphatidylethanolamine (DOPE). This amphipathic lipid is used in mixtures with dioleoylphosphatidylethanolamine (DOPE) to form ′pH sensitive′ fusogenic vesicles. It can control cell growth.

Properties of Cholesteryl hemisuccinate

Melting point: 178 °C
Boiling point: 586.0±43.0 °C(Predicted)
Density  1.06±0.1 g/cm3(Predicted)
refractive index  -34 ° (C=2, CHCl3)
storage temp.  -20°C
solubility  Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
pka 4.40±0.17(Predicted)
form  Solid
color  White to Off-White
CAS DataBase Reference 1510-21-0(CAS DataBase Reference)

Safety information for Cholesteryl hemisuccinate

Computed Descriptors for Cholesteryl hemisuccinate

InChIKey WLNARFZDISHUGS-BLYFUZNHSA-N

Related products of tetrahydrofuran

You may like

  • Cholesterol Hydrogen Succinate CAS 1510-21-0
    Cholesterol Hydrogen Succinate CAS 1510-21-0
    1510-21-0
    View Details
  • CHEMS CAS 1510-21-0
    CHEMS CAS 1510-21-0
    1510-21-0
    View Details
  • Cholesteryl hemisuccinate CAS 1510-21-0
    Cholesteryl hemisuccinate CAS 1510-21-0
    1510-21-0
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.