Cholesteryl oleate
Synonym(s):3β-Hydroxy-5-cholestene 3-oleate;5-Cholesten-3β-ol 3-oleate;Cholesteryl cis-9-octadecenoate;Oleic acid cholesteryl ester
- CAS NO.：303-43-5
- Empirical Formula: C45H78O2
- Molecular Weight: 651.12
- MDL number: MFCD00003645
- EINECS: 206-142-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is Cholesteryl oleate ?
Description
Cholesteryl oleate is a cholesterol ester. It has been used in the generation of nanoparticles and liposomes for drug delivery.
Chemical properties
white to off-white powder, lumpy powder or pale
The Uses of Cholesteryl oleate
Cholesteryl oleate was used to study the ability of silicone hydrogel contact lenses to absorb tear lipids, cholesterol and cholesterol esters. It was also used in the development of amperometric cholesterol biosensors.
What are the applications of Application
Cholesteryl oleate is an esterified form cholesterol found in plasma
Definition
ChEBI: The (Z)-stereoisomer of cholesteryl octadec-9-enoate.
Biochem/physiol Actions
Cholesterol in plasma is present in an esterified form such as Cholesteryl oleate. The liver is a primary source of cholesteryl oleate that enriches the LDL particles when released into plasma. The secretion of lipoproteins enriched with cholesteryl oleate has close correlation with the pathogenesis of coronary artery atherosclerosis.
Purification Methods
Purify the oleate ester by chromatography on silica gel and eluting with MeOH. [Beilstein 6 III 2642.]
Properties of Cholesteryl oleate
| Melting point: | 44-47 °C (lit.) |
| Boiling point: | 617.95°C (rough estimate) |
| Density | 0.9287 (rough estimate) |
| refractive index | -20 ° (C=2, THF) |
| Flash point: | >230 °F |
| storage temp. | -20°C |
| solubility | chloroform: 0.1 g/mL, clear, colorless |
| form | Solid |
| color | White to Off-White Low-Melting |
| BRN | 2343071 |
| CAS DataBase Reference | 303-43-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Cholesteryl oleate(303-43-5) |
| EPA Substance Registry System | Cholest-5-en-3-ol (3.beta.)-, (9Z)-9-octadecenoate (303-43-5) |
Safety information for Cholesteryl oleate
Computed Descriptors for Cholesteryl oleate
Cholesteryl oleate manufacturer
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