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HomeProduct name listCefpiramide acid

Cefpiramide acid

  • CAS NO.:70797-11-4
  • Empirical Formula: C25H24N8O7S2
  • Molecular Weight: 612.64
  • MDL number: MFCD00864893
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 11:59:05
Cefpiramide acid Structural

What is Cefpiramide acid?

Absorption

Rapidly absorbed following intramuscular injection.

Toxicity

Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.

The Uses of Cefpiramide acid

Antibacterial.

The Uses of Cefpiramide acid

Cefpiramide is used as a β-lactam antibiotic.

Indications

For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa.

Background

Cefpiramide is a third-generation cephalosporin antibiotic.

What are the applications of Application

Cefpiramide is β-lactam antibiotic

Definition

ChEBI: A third-generation cephalosporin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and (R)-2-{[(4-hydroxy-6-methylpyridin-3-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectiv ly, of the cephem skeleton. It has a broad spectrum of antibacterial activity.

Antimicrobial activity

A semisynthetic parenteral cephalosporin. It exhibits a broad range of activity, which includes Ps. aeruginosa, though the overall activity is rather modest. It is moderately stable to most β-lactamases but less so than ceftazidime or cefpirome.
In volunteers given 0.5 or 1 g by intravenous bolus, the mean plasma concentration shortly after injection was around 150 or 300 mg/L, respectively. There was no accumulation when the same doses were repeated every 12 h for 11 doses. It is highly bound to plasma protein (c. 95%). The mean plasma half-life is around 5 h. Less than one-quarter of the dose appears in the urine over 24 h; the rest is excreted in bile and high concentrations are found in feces. Renal impairment has little effect on elimination in patients with normal liver function.
Diarrhea may be associated with marked suppression of gut flora resulting from biliary excretion of the drug. The molecule includes a C-3 methylthiotetrazole side chain and side effects associated with that substituent are to be expected.
It is available in Japan.

Pharmacokinetics

Cefpiramide is a cephalosporin active against Pseudomonas aeruginosa. It has a broad spectrum of antibacterial activity. Cefpiramide works by inhibiting bacterial cell wall biosynthesis. The plasma half-lives of cefpiramide in rabbits, dogs, and rhesus monkeys were much longer than those of cefoperazone and cefazolin.

Metabolism

Not Available

Properties of Cefpiramide acid

Melting point: 213-215° (dec)
Density  1.75±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer, Under Inert Atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 2.62±0.50(Predicted)
color  White

Safety information for Cefpiramide acid

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Cefpiramide acid

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