Cefoselis
- CAS NO.:122841-10-5
- Empirical Formula: C19H22N8O6S2
- Molecular Weight: 522.56
- MDL number: MFCD00864846
- EINECS: 1533716-785-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is Cefoselis?
Description
Cefotaxime (cefoselis, FK037) is a fourth-generation cephalosporin. Compared with the commonly used third-generation cephalosporins, it has a wider antibacterial spectrum and has enhanced effects on AmpCβ-lactamase-producing Enterobacteriaceae bacteria.
The Uses of Cefoselis
Cefoselis can inhibit the cross-linking of mucinous peptide chains in the process of cell wall synthesis, so that bacteria cannot form a complete cell wall; eventually induce sensitive bacteria to form filaments, so that the bacteria eventually dissolve and die.
Biological Activity
cefoselis is a widely used antibiotic of β-lactam [1].cefoselis has a large antibacterial spectrum against gram positive bacterium. it is a 4th generation of cephalosporin. cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. through testing the dialysate and blood samples by hplc, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. in renal failure rats, the elimination half-lives of cefoselis are prolonged. it may be one factor of the seizures caused by cefoselis. in addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of gaba, suggesting that cefoselis induces seizures through blocking the gaba receptors [1].
References
[1] ohtaki k, matsubara k, fujimaru s, shimizu k, awaya t, suno m, chiba k, hayase n, shiono h. cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. j neural transm. 2004 dec;111(12):1523-35.
Properties of Cefoselis
Density | 1.83±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | Powder |
pka | 2.77±0.50(Predicted) |
CAS DataBase Reference | 122841-10-5(CAS DataBase Reference) |
Safety information for Cefoselis
Computed Descriptors for Cefoselis
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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