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HomeProduct name listCefoselis

Cefoselis

  • CAS NO.:122841-10-5
  • Empirical Formula: C19H22N8O6S2
  • Molecular Weight: 522.56
  • MDL number: MFCD00864846
  • EINECS: 1533716-785-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-21 10:59:17
Cefoselis Structural

What is Cefoselis?

Description

Cefotaxime (cefoselis, FK037) is a fourth-generation cephalosporin. Compared with the commonly used third-generation cephalosporins, it has a wider antibacterial spectrum and has enhanced effects on AmpCβ-lactamase-producing Enterobacteriaceae bacteria.

The Uses of Cefoselis

Cefoselis can inhibit the cross-linking of mucinous peptide chains in the process of cell wall synthesis, so that bacteria cannot form a complete cell wall; eventually induce sensitive bacteria to form filaments, so that the bacteria eventually dissolve and die.

Biological Activity

cefoselis is a widely used antibiotic of β-lactam [1].cefoselis has a large antibacterial spectrum against gram positive bacterium. it is a 4th generation of cephalosporin. cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. through testing the dialysate and blood samples by hplc, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. in renal failure rats, the elimination half-lives of cefoselis are prolonged. it may be one factor of the seizures caused by cefoselis. in addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of gaba, suggesting that cefoselis induces seizures through blocking the gaba receptors [1].

References

[1] ohtaki k, matsubara k, fujimaru s, shimizu k, awaya t, suno m, chiba k, hayase n, shiono h. cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. j neural transm. 2004 dec;111(12):1523-35.

Properties of Cefoselis

Density  1.83±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
form  Powder
pka 2.77±0.50(Predicted)
CAS DataBase Reference 122841-10-5(CAS DataBase Reference)

Safety information for Cefoselis

Computed Descriptors for Cefoselis

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