Guaiacol

Absorption

In rats, guaiacol is rapidly absorbed, being present in the blood 5 minutes after oral administration, and reaching its peak plasma concentration in about 10 minutes. Its elimination from the blood is usually as rapid.

Description

Guaiacol, or?o-methoxyphenol, was first isolated from the tree resin guaiac by A. Sobrero in 1843. Today, it is manufactured by methylating catechol (o-dihydroxybenzene). It is used medically as an expectorant, antiseptic, and local anesthetic; it is also a precursor to flavorants and aromas,?including those incorporated in synthetic sandalwood.

The Uses of Guaiacol

Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.

Background

Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.

Indications

It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation.

What are the applications of Application

Guaiacol is a phenolic natural product and reducing co-substrate for COX reactions

Metabolism

Not Available