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122841-10-5

122841-10-5 structural image
Product Name: Cefoselis
Formula: C19H22N8O6S2
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COMPUTED DESCRIPTORS

Molecular Weight 522.6 g/mol
XLogP3 -0.9
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 8
Exact Mass 522.11037280 g/mol
Monoisotopic Mass 522.11037280 g/mol
Topological Polar Surface Area 259 Ų
Heavy Atom Count 35
Formal Charge 0
Complexity 930
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Cefoselis is a semisynthetic, broad-spectrum, beta-lactamase-resistant, fourth-generation cephalosporin with antibacterial activity. Cefoselis binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.