Calcium levofolinate
- CAS NO.：80433-71-2
- Empirical Formula: C20H25CaN7O7
- Molecular Weight: 515.54
- MDL number: MFCD00865527
- EINECS: 801-530-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Calcium levofolinate?
Description
L-Folinic acid is a reduced folic acid and isomer of DL-folinic acid . DL-Folinic acid is a racemic mixture of D-folinic acid and L-folinic acid that has been used to prevent toxicity following therapy with high-dose methotrexate , to enhance the antitumor activity of 5-fluorouracil , and as a folate supplement. Clinical studies demonstrate that formulations containing L-folinic acid have similar efficacy and tolerability as those contianing DL-folinic acid and have been used interchangeably for modification of antitumor activity of 5-fluorouracil, while D-folinic acid is inactive.
Chemical properties
Off-White to Light Beige Amorphous Powder
The Uses of Calcium levofolinate
Calcium levofolinate is a pharmaceutical drug that is used in biological studies for the treatment of colorectal cancer.
The Uses of Calcium levofolinate
It is an intermediate product of the metabolism of Folic Acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process.
The Uses of Calcium levofolinate
intermediate from Folic Acid metabolism
Properties of Calcium levofolinate
| Melting point: | 240-2500C (dec) |
| alpha | D20 -15.1° (c = 1.82) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Slightly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). |
| form | Solid |
| color | Off-White to Pale Beige |
| Stability: | Hygroscopic, Light Sensitive |
| CAS DataBase Reference | 80433-71-2(CAS DataBase Reference) |
Safety information for Calcium levofolinate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Calcium levofolinate
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