Benzyloxyacetyl chloride

CAS NO.：19810-31-2
Empirical Formula: C9H9ClO2
Molecular Weight: 184.62
MDL number: MFCD00010768
EINECS: 629-534-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-27 16:27:43

What is Benzyloxyacetyl chloride?

Chemical properties

Colorless to yellow liquid

The Uses of Benzyloxyacetyl chloride

Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.

The Uses of Benzyloxyacetyl chloride

Commonly employed reagent for asymmetric synthesis of β-lactams.1,2

Properties of Benzyloxyacetyl chloride

Melting point:	120 °C (decomp)
Boiling point:	84-87 °C/0.4 mmHg (lit.)
Density	1.17 g/mL at 25 °C (lit.)
refractive index	n20/D 1.523(lit.)
Flash point:	>230 °F
storage temp.	2-8°C
form	Powder or Cyrstals
color	White
Water Solubility	Reacts with water.
Sensitive	Moisture Sensitive
BRN	1947363
CAS DataBase Reference	19810-31-2(CAS DataBase Reference)

Safety information for Benzyloxyacetyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.