ARV-771

CAS NO.：1949837-12-0
Empirical Formula: C49H60ClN9O7S2
Molecular Weight: 986.65
MDL number: MFCD30738017
Update Date: 2024-11-13 11:39:26

What is ARV-771?

Description

ARV-771 is a BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2), respectively.

The Uses of ARV-771

ARV-771 is an effective BET degrader of the PROTAC class.

Biological Activity

ARV-771 is a potent pan-(bromodomain and extra-terminal) BET degrader, a novel BET-PROTAC (proteolysis-targeting chimera), for BRD2(1), BRD2(2), BRD3(1) The Kd values of , BRD3(2), BRD4(1) and BRD4(2) were 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM, respectively.

storage

Store at -20°C

Properties of ARV-771

Density	1.39±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO:65.92(Max Conc. mg/mL);68.22(Max Conc. mM) DMF:20.0(Max Conc. mg/mL);20.7(Max Conc. mM) DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.14(Max Conc. mM) Ethanol:55.0(Max Conc. mg/mL);56.92(Max Conc. mM)
form	A crystalline solid
pka	13.61±0.46(Predicted)
color	White to light yellow

Safety information for ARV-771

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.