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HomeProduct name listBaloxavir

Baloxavir

  • CAS NO.:1985605-59-1
  • Empirical Formula: C24H19F2N3O4S
  • Molecular Weight: 483.49
  • MDL number: MFCD31619273
  • EINECS: 200-001-8
  • Update Date: 2024-11-18 17:01:59
Baloxavir Structural

What is Baloxavir?

The Uses of Baloxavir

Baloxavir is a drug employed in the treatment of influenza virus infection.

Mechanism of action

Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.

Side Effects

Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.

Properties of Baloxavir

Boiling point: 644.7±65.0 °C(Predicted)
Density  1.63±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM)
form  A solid
pka 4.50±1.00(Predicted)
color  White to yellow
CAS DataBase Reference 1985605-59-1

Safety information for Baloxavir

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Baloxavir

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