Baloxavir
- CAS NO.:1985605-59-1
- Empirical Formula: C24H19F2N3O4S
- Molecular Weight: 483.49
- MDL number: MFCD31619273
- EINECS: 200-001-8
- Update Date: 2024-09-19 20:58:09
What is Baloxavir?
The Uses of Baloxavir
Baloxavir is a drug employed in the treatment of influenza virus infection.
Mechanism of action
Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.
Side Effects
Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.
Properties of Baloxavir
Boiling point: | 644.7±65.0 °C(Predicted) |
Density | 1.63±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM) |
form | A solid |
pka | 4.50±1.00(Predicted) |
color | White to yellow |
CAS DataBase Reference | 1985605-59-1 |
Safety information for Baloxavir
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Baloxavir
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin E Tubulysin C Tubulysin G Tubulysin M Tubulysin A Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 3-Morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-Fluorophenyl)piperidin-2-one Diethyl 2,5-di(furan-2-yl)terephthalate Methyl 4-amino-3-(piperidin-1-yl)benzoate Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 2,2-dibromopropanoate (±)-1-Phenylethane ethane sulfonic acidRelated products of tetrahydrofuran
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