alpha-Toluenesulfonyl chloride

Synonym(s):α-Toluenesulfonyl chloride

CAS NO.：1939-99-7
Empirical Formula: C7H7ClO2S
Molecular Weight: 190.65
MDL number: MFCD00007455
EINECS: 217-717-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-19 17:35:41

alpha-Toluenesulfonyl chloride Structural

What is alpha-Toluenesulfonyl chloride?

Chemical properties

almost white crystalline powder

The Uses of alpha-Toluenesulfonyl chloride

a-Toluenesulfonyl Chloride inhibits intracellular protein breakdown in the L1210 ascites leukemia in mouse. It also functions as a reagent for the protection of amino groups as benzylsulfonamides which can be cleaved off through reduction.

What are the applications of Application

Phenylmethanesulfonyl chloride is an aliphatic sulfonyl chloride

Synthesis Reference(s)

The Journal of Organic Chemistry, 16, p. 621, 1951 DOI: 10.1021/jo01144a013
Synthesis, p. 1203, 1992 DOI: 10.1055/s-1992-26333

General Description

Phenylmethanesulfonyl chloride is an aliphatic sulfonyl chloride. It reacts with triethylamine in methylene chloride or ether to yield trans-stilbene and cis diphenylethylene sulfone. Its reaction with 1,1-bis(diethylamino)ethane has been studied. Addition of phenylmethanesulfonyl chloride to 1,3-diphenyl-2-pyrrolidinopropene in the presence of water was studied.

Properties of alpha-Toluenesulfonyl chloride

Melting point:	92-94 °C(lit.)
Boiling point:	120 °C / 10mmHg
Density	1.3264 (estimate)
refractive index	1.624-1.626
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Toluene
form	Crystalline Powder
color	Almost white
Water Solubility	decomposes
Sensitive	Moisture Sensitive
BRN	972806
CAS DataBase Reference	1939-99-7(CAS DataBase Reference)
NIST Chemistry Reference	Benzenemethanesulfonyl chloride(1939-99-7)
EPA Substance Registry System	Benzenemethanesulfonyl chloride (1939-99-7)

Safety information for alpha-Toluenesulfonyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.