4-Nitrobenzenesulfonyl chloride

Chemical properties

yellow to brown powder, soluble in toluene,tetrahydrofuran,methylene chloride and ethyl acetate. Insoluble in water.

The Uses of 4-Nitrobenzenesulfonyl chloride

4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.

The Uses of 4-Nitrobenzenesulfonyl chloride

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).

Production Methods

4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.

Flammability and Explosibility

Not classified