Ethanesulfonyl chloride

CAS NO.：594-44-5
Empirical Formula: C2H5ClO2S
Molecular Weight: 128.58
MDL number: MFCD00007460
EINECS: 209-842-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-01 23:06:22

What is Ethanesulfonyl chloride?

Chemical properties

clear light brownish to pinkish-purple liquid

The Uses of Ethanesulfonyl chloride

Chloroethylsulfone was used in discovery of a selective inhibitor of oncogenic B-raf kinase with potent antimelanoma activity.

What are the applications of Application

Ethanesulfonyl chloride can make sulfonyl-substituted imides, methide lithium salts, and pentafluoroethanesulfonyl fluoride, a fluorinated surfactant. It is an intermediate in synthesizing new, low-cost, non-fluorinated, sulfonyl-substituted imide and methide lithium salts and an intermediate in preparing the fluorinated surfactant pentafluoroethanesulfonyl fluoride.

Synthesis Reference(s)

Journal of the American Chemical Society, 61, p. 2548, 1939 DOI: 10.1021/ja01878a085

Properties of Ethanesulfonyl chloride

Melting point:	-70°C
Boiling point:	177 °C (lit.)
Density	1.357 g/mL at 25 °C (lit.)
refractive index	n20/D 1.452(lit.)
Flash point:	182 °F
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in dichloromethane,Ether
form	Liquid
color	Clear colorless to light yellow or light brownish to pinkish-purple
Water Solubility	DECOMPOSES
Sensitive	Moisture Sensitive
BRN	773865
CAS DataBase Reference	594-44-5(CAS DataBase Reference)
NIST Chemistry Reference	Ethanesulfonyl chloride(594-44-5)
EPA Substance Registry System	Ethanesulfonyl chloride (594-44-5)

Safety information for Ethanesulfonyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H314:Skin corrosion/irritation H330:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.