AG 18

Synonym(s):α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810;(3,4-Dihydroxybenzylidene)malononitrile;AG 18 - CAS 118409-57-7 - Calbiochem;RG-50810

CAS NO.：118409-57-7
Empirical Formula: C10H6N2O2
Molecular Weight: 186.17
MDL number: MFCD00133899
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is AG 18?

Chemical properties

Yellow Powder

The Uses of AG 18

AG 18 inhibits EGFR with IC50 of 35 μM.

The Uses of AG 18

A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).

What are the applications of Application

Tyrphostin A23 is an agent that blocks EGF-dependent autophosphorylation

Definition

ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Properties of AG 18

Melting point:	225°C
Boiling point:	421.1±45.0 °C(Predicted)
Density	1.428±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO, ethanol, or DMF
form	Yellow solid
pka	7.26±0.18(Predicted)
color	Yellow
λmax	464nm(DMSO)(lit.)
Stability:	Store in refrigerator

Safety information for AG 18

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H371:Specific target organ toxicity, single exposure H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up.