AG 18
Synonym(s):α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810;(3,4-Dihydroxybenzylidene)malononitrile;AG 18 - CAS 118409-57-7 - Calbiochem;RG-50810
- CAS NO.：118409-57-7
- Empirical Formula: C10H6N2O2
- Molecular Weight: 186.17
- MDL number: MFCD00133899
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-23 21:30:31
What is AG 18?
Chemical properties
Yellow Powder
The Uses of AG 18
AG 18 inhibits EGFR with IC50 of 35 μM.
The Uses of AG 18
A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
What are the applications of Application
Tyrphostin A23 is an agent that blocks EGF-dependent autophosphorylation
Definition
ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.
Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Properties of AG 18
| Melting point: | 225°C |
| Boiling point: | 421.1±45.0 °C(Predicted) |
| Density | 1.428±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO, ethanol, or DMF |
| form | Yellow solid |
| pka | 7.26±0.18(Predicted) |
| color | Yellow |
| λmax | 464nm(DMSO)(lit.) |
| Stability: | Store in refrigerator |
Safety information for AG 18
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H371:Specific target organ toxicity, single exposure H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. |
Computed Descriptors for AG 18
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
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