AG 18
Synonym(s):α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810;(3,4-Dihydroxybenzylidene)malononitrile;AG 18 - CAS 118409-57-7 - Calbiochem;RG-50810
- CAS NO.:118409-57-7
- Empirical Formula: C10H6N2O2
- Molecular Weight: 186.17
- MDL number: MFCD00133899
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 21:40:10
What is AG 18?
Chemical properties
Yellow Powder
The Uses of AG 18
AG 18 inhibits EGFR with IC50 of 35 μM.
The Uses of AG 18
A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
What are the applications of Application
Tyrphostin A23 is an agent that blocks EGF-dependent autophosphorylation
Definition
ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.
Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Properties of AG 18
Melting point: | 225°C |
Boiling point: | 421.1±45.0 °C(Predicted) |
Density | 1.428±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO, ethanol, or DMF |
form | Yellow solid |
pka | 7.26±0.18(Predicted) |
color | Yellow |
λmax | 464nm(DMSO)(lit.) |
Stability: | Store in refrigerator |
Safety information for AG 18
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H371:Specific target organ toxicity, single exposure H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. |
Computed Descriptors for AG 18
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