TYRPHOSTIN A9
Synonym(s):[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AG 17 - CAS 10537-47-0 - Calbiochem;Malonoben;NSC 242557, 3,5-di- t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di- t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
- CAS NO.:10537-47-0
- Empirical Formula: C18H22N2O
- Molecular Weight: 282.38
- MDL number: MFCD00209853
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:34
What is TYRPHOSTIN A9?
Description
Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4
The Uses of TYRPHOSTIN A9
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
The Uses of TYRPHOSTIN A9
SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.
The Uses of TYRPHOSTIN A9
Selective inhibitor of PDGF receptor tyrosine kinase
What are the applications of Application
Tyrphostin 9 is a PDGFR and calcium inhibitor
Definition
ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.
General Description
A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
Biological Activity
Potent uncoupler of oxidative phosphorylation.
Biochem/physiol Actions
Cell permeable: yes
References
1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721 2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225 3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794 4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33
Properties of TYRPHOSTIN A9
Melting point: | 141-143℃ (ethanol ) |
Boiling point: | 424.99°C (rough estimate) |
Density | 1.0741 (rough estimate) |
refractive index | 1.5700 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | ethanol: 20 mg/mL |
form | solid |
pka | 7.55±0.40(Predicted) |
color | yellow |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 10537-47-0(CAS DataBase Reference) |
EPA Substance Registry System | Malonoben (10537-47-0) |
Safety information for TYRPHOSTIN A9
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for TYRPHOSTIN A9
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