TYRPHOSTIN AG 126
Synonym(s):α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile;AG 126 - CAS 118409-62-4 - Calbiochem
- CAS NO.:118409-62-4
- Empirical Formula: C10H5N3O3
- Molecular Weight: 215.16
- MDL number: MFCD00236448
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 13:44:46
What is TYRPHOSTIN AG 126?
What are the applications of Application
AG 126 is selectively inhibits phosphorylation of ERK 1 and ERK 2
Definition
ChEBI: 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.
Biological Activity
ag-126 is an erk1 and erk2 inhibitor.extracellular signal-regulated kinases (erks) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the erk pathway.
in vitro
previous study found that r ag126 ould potently inhibit the pcw-evoked release and this effect was rather selective with respect to the stimulus. ag126 was found to be less potent in attenuating lps-triggered release. moreover, it was found that ag126 was able to prevent the pcw-inducible erk phosphorylation, which could relate to the ag126-mediated inhibition of pcw-evoked cytokine release [1].
in vivo
ag126 was tested in a model of pcw-induced meningitis, in which rats underwent intracisternal injection of pcw with and without ag126 pretreatment. pcw injection led to a dramatic leukocyte influx into the csf. ag126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. in addition, ag126 treatment showed beneficial effects on other parameters, such as intracranial pressure. furthermore, ag126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial pao2, paco2 as well as ph [1].
References
[1] hanisch, u. k.,prinz, m.,angstwurm, k., et al. the protein tyrosine kinase inhibitor ag126 prevents the massive microglial cytokine induction by pneumococcal cell walls. european journal of immunology 31, 2104-2115 (2001).
Properties of TYRPHOSTIN AG 126
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | ≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide |
form | Yellow solid |
color | Light yellow to yellow |
Sensitive | Light Sensitive |
Safety information for TYRPHOSTIN AG 126
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for TYRPHOSTIN AG 126
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