NS-398
Synonym(s):N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide;N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide;NS-398 - CAS 123653-11-2 - Calbiochem
- CAS NO.:123653-11-2
- Empirical Formula: C13H18N2O5S
- Molecular Weight: 314.36
- MDL number: MFCD00882995
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-22 17:12:53
What is NS-398?
Description
NS-
The Uses of NS-398
NS-398 is a selective Cox-2 inhibitor neuroprotective agent.
What are the applications of Application
NS-398 is a selective Cox-2 inhibitor neuroprotective agent
Definition
ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Biological Activity
Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
storage
Store at RT
References
[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.
Properties of NS-398
Melting point: | 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
Boiling point: | 490.6±55.0 °C(Predicted) |
Density | 1.377±0.06 g/cm3(Predicted) |
RTECS | PB0473500 |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: >5 mg/mL |
form | solid |
pka | 6.33±0.10(Predicted) |
color | off-white |
Safety information for NS-398
Computed Descriptors for NS-398
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin E Tubulysin C Tubulysin H (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 4-Bromo-N,N-bis(4-iodophenyl)aniline 2-(4-Bromopyridin-2-yl)acetonitrile 1-(4-Chlorophenyl)piperidin-2-one 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (-)-1-Phenyl ethane sulfonic acid 6-Hydroxyisoquinoline 4-bromo-7H-pyrrolo[2,3-d]pyrimidineRelated products of tetrahydrofuran
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