AG 99
- CAS NO.:122520-85-8
- Empirical Formula: C10H8N2O3
- Molecular Weight: 204.18
- MDL number: MFCD00133901
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is AG 99?
The Uses of AG 99
Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .
References
[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.
Properties of AG 99
Melting point: | 247 °C |
Boiling point: | 544.4±50.0 °C(Predicted) |
Density | 1.482±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Soluble in DMSO |
pka | 8.81±0.10(Predicted) |
form | Brown solid. |
color | Light yellow to yellow |
Safety information for AG 99
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for AG 99
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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